We study planarian flatworms, which can regenerate entire animals by activation of pluripotent stem cells. Our goal is to determine how stem cells respond to injuries and restore missing organs.

Intestinal stem cells, host-microbe interactions, gut homeostasis, gut physiology and metabolism, innate immune response, gene regulatory networks, systems biology

Gene expression, transcriptional regulation, enhancers, promoters, non-coding DNA

We work at the interface of cancer biology and immunology with a focus on understanding how cancer cell-intrinsic and extrinsic factors regulate anti-tumor immunity and resistance to immune checkpoint blockade therapies in the context of breast cancers.

Mitochondrial genes; nuclear gene regulation

My laboratory investigates post-transcriptional gene regulation, using experimental and computational genomics, together with traditional experimental approaches. Projects include mechanistic and in vivo studies of post-transcriptional regulation.

To determine the underlying cause of the illness Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, we use analyses of gene expression, immune cell function, proteomics, metabolomics, and statistical and computational tools.

We use and develop genetic and genomic tools to identify and characterize the genetic pathways regulating how fungi sense and respond to their environment.

Identifying regulatory regions of the genome in human population; regulation of RNA lifespan in stress response; single cell epigenomics

Our research interests focus on molecular mechanisms by which promoters and enhancers regulate gene expression. We use state-of-the-art genome-wide assays and analyses to evaluate the interplay of chromatin architecture and transcription regulation.

My research probes gene regulatory mechanisms that control neuronal identity and function during brain development and how they misfunction in autism and other neurodevelopmental disorders.

Research in the Nwosu Lab focuses on understanding the metabolic alterations that drive cancer, the involvement of tumor microenvironment cells in modulating metabolism, and ways to effectively target metabolism to improve cancer treatment

Translational regulation, RNA modification, genetic recoding

We study molecular mechanisms of enhancer-promoter communication in humans and yeast, involving genome-wide ChIP-exo/seq and computational (AI) techniques. From cancer to condensates.

RNA biology, translational regulation, protein quality control